Process of making solid ribavirin dosage forms

A method of producing a rapidly dissolving compacted ribavirin composition which comprises the steps of:

• (a) admixing an antivirally effective amount of ribavirin, an effective amount of a pharmaceutically acceptable disintegrant, and an effective amount of at least one filler for a time sufficient and at a temperature wherein the heat produced is insufficient;
• and to form a homogeneous mixture;
• b) compacting the homogeneous mixture of Step (a) at a compressing force in the range of about 50 to about 75 kN for a time sufficient to produce an acceptable compact wherein the ribavirin is substantially free of polymorphic forms of ribavirin;
• c) admixing the acceptable compact of Step (b) with an effective amount of a lubricant for a time sufficient to produce a uniform, rapidly dissolving compacted ribavirin composition having a uniformly high tap density of at least about 0.60 glmL and wherein 80% of the rapidly dissolving compacted ribavirin composition dissolves in water in about 30 minutes.