Parvovirus protein presenting capsids
AssigneeUnited States of America
InventorsNeal S. Young, Sachiko Kajigaya, Shimada Takashi
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Abstract
The present invention relates to a parvovirus protein presenting capsid. Protein presenting capsid can be made by substituting nonparvovirus proteins, such as antigenic epitopes, ligands, enzymes, or peptide sequences, for the unique region of the parvovirus minor structural protein (e.g. VP1). Small regions of VP2 can also be replaced. Normal VP2 can be added to enhance capsid formation.
Claims11
A protein presenting capsid comprising a modified B19 parvovirus VP1 minor capsid protein, wherein the modification is substitution of some or all of the unique region of VP1 with a heterologous protein sequence.
A protein presenting capsid, comprising B19 VP2 major capsid protein and a modified VP2 major capsid protein, wherein the modification is insertion of a heterologous sequence at VP2 amino acid position 276.
Dependencies are inferred from the claim text.