Polymer protein composites and methods for their preparation and use
AssigneeBiotechnology Research and Development Corporation
InventorsJonathan S. Dordick, Ping Wang, Maria Vladimir Sergeeva, Scott Joel Novick
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Abstract
A method of preparing a polymer-protein composite including polymerizing a monomer in the presence of a protein dissolved in an organic phase via the ion-pairing of the protein with a surfactant. The polymer-protein composites are useful, for example, as highly active and stable catalysts, in for example, paints and coatings, as well as in medical application.
Claims23
A method of preparing a polymer-protein composite comprising polymerizing a monomer via addition, condensation, or ring-opening polymerization in the presence of a protein dissolved in an organic phase via a ion-pairing of the protein with a surfactant, to thereby form said polymer protein composite.
A method of preparing a polymer-protein composite that comprises
- dissolving a protein in an aqueous buffered solution to form a protein solution,
- optionally chemically modifying the protein with a polymerizable functional group,
- dissolving a surfactant into an organic solvent to form a surfactant solution,
- adding the protein solution to the surfactant solution thereby forming an organic phase containing an ion-paired protein-surfactant complex,
- separating out the organic phase that contains the complex,
- optionally drying the separated out organic phase by removing the organic solvent and optionally adding additional organic solvent to the organic phase to redissolve the protein-surfactant complex,
- adding a monomer to the protein-surfactant complex, which is either in an organic phase or in a dried state, and polymerizing the monomer to form the polymer-protein composite, and
- recovering the polymer-protein composite.
A method of preparing a polymer-protein composite comprising polymerizing a monomer in the presence of a protein dissolved in an organic phase via the ion-pairing of the protein with a surfactant, to thereby form a polymer-protein composite.
Dependencies are inferred from the claim text.