Bioactive load bearing bone bonding compositions
AssigneeOrthovita, Inc.
InventorErik M. Erbe
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Abstract
Novel fillers comprising combeite glass-ceramic are provided, along with filled polymerizable resin composites. Further provided are methods for making the combeite crystallite-containing novel fillers for use in hardenable, biocompatible bone restorations. Hard, shaped bodies or orthopaedic, dental and other uses are also provided.
Claims52
A glass-ceramic composition comprising heterogeneous particles having an irregular morphology and regions of combeite crystallites.
A method for restoring bone comprising applying to said bone a hardenable composition comprising a polymerizable matrix and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite.
A method for preparing a bioactive, inorganic, particulate filler comprising:
- melting together about 34 percent by weight SiO.sub.2, about 31 percent by weight Na.sub.2 CO.sub.3, about 26.5 percent by weight CaCO.sub.3, and about 8.5 percent by weight CaHPO.sub.4 for a time and under conditions effective to achieve substantial homogeneity;
- casting, crystallizing and cooling the melt into a body;
- comminuting said body to form particles having irregular morphology;
- determining the presence or absence and amount of regions of combeite crystallites in said particles;
- and
- in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
A method for preparing a bioactive, inorganic, particulate filler comprising:
- melting together about 45 percent by weight SiO.sub.2, about 24.5 percent by weight Na.sub.2 O, about 24.5 percent by weight CaO, and about 6 percent by weight P.sub.2 O.sub.5 for a time and under conditions effective to achieve substantial homogeneity;
- quenching said melt in a fluid to form a frangible frit;
- comminuting said freL to form particles having irregular morphology;
- determining the presence or absence and amount of regions of combeite crystallites in said particles;
- and
- in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
A shaped body comprising a polymerized matrix filled with an inorganic filler, at least 10% of said filler comprising combeite glass-ceramic having at least 2% by volume of regions of combeite and irregular morphology.
Dependencies are inferred from the claim text.