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US 5,912,260 AGranted
Gastrin and CCK antagonists
AssigneeJames Black Foundation Limited
InventorsSarkis Barret Kalindjian, Nigel Paul Shankley, Robert Antony David Hull, Atul Kotecha, Sonia Patricia Roberts, Elaine Anne Harper
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Abstract
Described herein are compounds of formula (I) or a pharmaceutically acceptable salt thereof, ##STR1## wherein L is N or C, one of X and Y is --NH--CH.sub.2 --R.sup.2 and the other is the substituent of formula (II). The compounds are potent gastrin and/or CCK antagonists.
Claims11
A compound of the formula ##STR8## wherein L is N or C,
- one of X and Y is --NH--CH.sub.2 --R.sup.2 (wherein R.sup.2 is cycloheptyl or 1-adamantyl) and the other is ##STR9## in which R.sup.1 is H or methyl, T.sub.1 and T.sup.2 are independently H or Z(CH.sub.2).sub.m --, wherein m is from 0 to 3 and Z is a carboxy group, a tetrazolyl group, CF.sub.3 CONHSO.sub.2 --, PhCONHSO.sub.2 --, isopropyl-OC(O)NHSO.sub.2 -- or a group selected from ##STR10## (provided that T.sup.1 and T.sup.2 are not both H and that T.sup.1 and T.sup.2 are not both carboxy when L is C);
- and
- n is from 0 to 5
- or a pharmaceutically acceptable salt or prodrug thereof.
1 more element
Dependencies are inferred from the claim text.