Delivery system for the localized administration of medicaments to the upper respiratory tract and methods for preparing and using same
AssigneeWarner-Lambert Company
InventorsPauline C. Pan, Shan Shan Sheu, Shiuh J. Luo
Life of this patent
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Abstract
The present invention pertains to delivery systems for the localized administration of a medicament to the upper respiratory tract. The delivery system comprises: (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract, (b) an ionic polysaccharide, and, (c) a cross-linking agent. This invention also pertains to the medicated compositions containing the targeted delivery system in a pharmaceutically acceptable carrier. The invention further pertains to methods for preparing and using the delivery systems and medicated compositions.
Claims27
A medicated composition for the localized administration of a medicament to the upper respiratory tract which comprises:
- (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract,
- (b) an ionic polysaccharide,
- (c) a cross-linking agent to polymerize the ionic polysaccharide wherein said cross-linking agent contains a multivalent ion selected from the group consisting of aluminum, calcium, copper, iron, magnesium, manganlese, zinc, and mixtures thereof,
- said components (a) (b) and (c) being incorporated into a carrier which is a soft confectionery material or a hard confectionery material, said confectionery material prepared from a high boiling syrup, said material suitable for administration of a medicament to the upper respiratory tract,
- wherein said medicament is present in an amount from about 0.001% to about 12%, by weight of the delivery system, said ionic polysaccharide is present in an amount from about 0.001% to about 1%, by weight of the composition, and, said cross-linking agent is present in an amount from about 0.001% to about 1.2%, by weight of the composition,
- such that said polymerization of said ionic polysaccharide takes place in said upper respiratory tract upon the dissolution of said carrier.
A method for preparing a medicated composition useful for the localized administration of medicaments to the upper respiratory tract which comprises the steps of:
- (1) providing the following ingredients:
- (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract,
- (b) an ionic polysaccharide,
- (c) a cross-linking agent to polymerize the ionic polysaccharide wherein said cross-lining agent contains a multivalent ion selected from the group consisting of aluminum, calcium, copper, iron, magnesium, manganese, zinc, and mixtures thereof, and,
- (d) a carrier which is a soft confectionery material or a hard confectionery material, said confectionery material prepared from a high boiling syrup, said material suitable for administration of a medicament to the upper respiratory tract,
- wherein said medicament is provided in an amount from about 0.001% to about 12%, by weight of the delivery system, said ionic polysaccharide is provided in an amount from about 0.001% to about 1%, by weight of the composition, and, said cross-linking agent is provided in an amount from about 0.001% to about 1.2%, by weight of the composition, such that said polymerization of said ionic polysaccharide takes place in said upper respiratory tract upon the dissolution of said carrier, and,
- (2) admixing the ingredients from step (1) to form the medicated composition.
A method for the local administration of a medicament to the upper respiratory tract of a patient which comprises orally administering a medicated composition which comprises:
- (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract,
- (b) an ionic polysaccharide,
- (c) a cross-linking agent to polymerize the ionic polysaccharide wherein said cross-linking agent contains a multivalent ion selected from the group consisting of aluminum, calcium, copper, iron, magnesium, manganese, zinc, and mixtures thereof,
- said components (a) (b) and (c) being incorporated into a carrier which is a soft confectionery material or a hard confectionery material, said confectionery material prepared from a high boiling syrup, said material suitable for administration of a medicament to the upper respiratory tract,
- wherein said medicament is present in an amount from about 0.001% to about 12%, by weight of the delivery system, said ionic polysaccharide is present in an amount from about 0.001% to about 1%, by weight of the composition, said, the cross-linking agent is present in an amount from about 0.001% to about 1.2%, by weight of the composition, such that said polymerization of said ionic polysaccharide takes place in said upper respiratory tract upon the dissolution of said carrier.
Dependencies are inferred from the claim text.