Method for iron delivery to a patient by transfer from dialysate
AssigneeHemocleanse, Inc.
InventorStephen R. Ash
Life of this patent
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Abstract
The invention relates to methods and compositions for delivering iron to an iron-deficient patient, more particularly, to methods whereby an iron complex comprising divalent or trivalent ionic iron complexed with one or more low molecular weight anions is administered to a patient by transfer from dialysate. A complex selected according to the invention is non-polymeric; soluble in an aqueous medium; chemically stable, thereby preventing the dissociation of iron ions from the anions under conditions according to the invention; and can be well absorbed into blood and the living body. Also provided are dialysate compositions including therein an iron complex selected according to the invention, and dialysate concentrates which may be diluted to yield an inventive dialysate composition.
Claims20
A method for delivering iron to blood comprising:
- providing a dialysate having dissolved therein a complex of one or more divalent or trivalent iron ions and one or more anions, the complex having a molecular weight of less than about 50,000;
- and
- dialyzing a patient with the dialysate to increase the level of iron in the patient's blood.
A method for delivering iron to blood, comprising:
- passing blood against a first side of a membrane;
- and
- passing against a second side of the membrane an aqueous solution having dissolved therein an iron complex comprising one or more iron ions and one or more anions;
- the complex having a molecular weight of less than about 12,000;
- wherein the membrane is permeable to the complex;
- and
- wherein the complex is delivered to the blood.
A method for delivering iron to a patient, comprising:
- introducing a dialysate into a patient's peritoneal cavity, the dialysate having dissolved therein a complex of one or more divalent or trivalent iron ions and one or more anions;
- wherein the complex has a molecular weight of less than about 50,000.
A method for the treatment of a patient to increase the level of iron in the patient's bloodstream, which comprises performing dialysis on the patient with a dialysate which comprises a soluble, low molecular weight iron complex;
- sodium;
- magnesium;
- calcium;
- potassium;
- chloride;
- acetate and bicarbonate.
A method for delivering iron to blood comprising:
- providing a dialysate having dissolved therein from about 0.008 to about 2 mg/dl ferrous gluconate;
- and
- dialyzing a patient with the dialysate to increase the level of iron in the patient's blood.
A composition comprising an aqueous medium having dissolved therein sodium, magnesium, calcium, potassium, chloride, acetate, bicarbonate and an iron complex having a molecular weight of less than about 50,000.
Dependencies are inferred from the claim text.