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US 5,906,821 AGranted
Viral nucleotide sequences
AssigneeRhone Merieux
InventorsAnnette Mary Griffin, Louis Joseph Norman Ross, Simon David Scott, Matthew McKinley Binns
Life of this patent
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AssigneeRhone Merieux
InventorsAnnette Mary Griffin, Louis Joseph Norman Ross, Simon David Scott, Matthew McKinley Binns
Estimating the term…
Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.
A non-naturally occurring insertional or deletional mutant of ILTV having a mutation in a gene selected from the group consisting of TK, ORF3 and ribonucleotide reductase, large subunit, genes.
Dependencies are inferred from the claim text.