Stable reverse and multiple fluorocarbon emulsions
AssigneeAlliance Pharmaceutical Corp.
InventorsJean G. Riess, Marie-Pierre Krafft
Life of this patent
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Abstract
Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.
Claims10
A stable water-in-oil fluorocarbon emulsion, comprising:
- a continuous oily phase comprising 70-99.5% (v/v) of at least one highly fluorinated or perfluorinated organic compound;
- a discontinuous aqueous phase dispersed in the continuous phase, wherein the amount of aqueous phase is between 0.05 and 30% (v/v) of the emulsion;
- and
- a fluorinated surfactant or a mixture of surfactants comprising at least one fluorinated surfactant,
- wherein the total amount of surfactant is between 0.01 and 10% (w/v) of the emulsion and
- wherein the reverse emulsion is a multiple water-in-fluorocarbon-in-water emulsion in an aqueous phase in which at least one surfactant is dispersed.
A multiple water-in-fluorocarbon-in-water emulsion according to claim 6, wherein the fluorinated surfactant is a (perfluoroalkyl)alkylene dimorpholinophosphate having the formula R.sub.F -R.sub.1 -OP(O) (N(CH.sub.2 CH.sub.2).sub.2 O!.sub.2, wherein R.sub.F is a linear, branched or cyclic highly fluorinated radical having from 2 to 12 carbon atoms and optionally contains at least one oxygen atom and/or at least one halogenated substituent selected from the group consisting of Cl and Br, or both, and R.sub.1 is a saturated or unsaturated, linear or branched hydrocarbon, optionally containing at least one oxygen atom, and/or at least one sulfur atom.
Dependencies are inferred from the claim text.