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US 5,904,931 AGranted
Transdermal therapeutic systems that contain sex steroids and dimethyl isosorbide
AssigneeSchering Corporation
InventorsRalph Lipp, Clemens Gunther, Jutta Riedl, Ulrich Tauber
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Abstract
Transdermal therapeutic systems that contain sex steroids and optionally penetration-enhancers and crystallization inhibitors are described, which are characterized in that they contain dimethyl isosorbide, with the exception of systems that contain active ingredient-containing, non-free-flowing gel phases or 3-keto-desogestrel.
Claims20
A transdermal therapeutic system comprising
- at least one matrix layer having an active ingredient phase comprising one or more sex steroids and, in an amount of 1 to 40% by weight relative to the entire active ingredient phase, dimethyl isosorbide, and
- a skin contact adhesive,
- provided that 3-keto-desogestrel is not one of the sex steroids and provided that the system does not contain an active ingredient-containing, non-free-flowing gel phase.
Dependencies are inferred from the claim text.