Method of removing beta-2 microglobulin from blood

A method of removing beta-2 microglobulin from blood, comprising the steps of removing blood from a patient, passing the blood through a material with a size and a structure selected so as to remove beta-2 microglobulin from the blood, re-entering the blood from which the beta-2 microglobulin is removed into the patient, wherein said material includes a hypercrosslinked polystyrene-type resins with surface of the beads modified so as to prevent absorption of large proteins and platelet and to minimize activation of blood complement system without affecting noticeably accessibility of an inner absorption space of the beads for small and middle-sized toxicant molecules.