Bone cement and method of preparation
AssigneeNorthwestern University
InventorsEugene P. Lautenschlager, Jeremy L. Gilbert, Peter Monaghan, Steven J. Duray, Richard L. Wixson
Life of this patent
Estimating the term…
Loading patent…
AssigneeNorthwestern University
InventorsEugene P. Lautenschlager, Jeremy L. Gilbert, Peter Monaghan, Steven J. Duray, Richard L. Wixson
Estimating the term…
Orthopedic bone cements of low porosity, prepared by mixing together at least two liquid components under conditions that allow only minimal exposure to air, are disclosed. In a preferred system, each liquid component consists essentially of a solution of a linear (non-crosslinked) polymer or copolymer of methyl methacrylate (PMMA) dissolved in a non-crosslinking methyl methacrylate (MMA) monomer, with one such solution also containing an activator and a polymerization inhibitor and a second solution containing an initiator as well as a polymerization inhibitor. No reinforcing fillers are present, although a small amount (no more than 12% by weight of the total cement composition) of a radiopacifier may be included in the composition. Since polymerization is initiated by mixing together two or more liquid solutions, and such mixing may be performed in a mixing chamber in which no air is required or is introduced during the mixing operation, prior problems of cement porosity and weakness resulting from air entrapment are avoided or greatly reduced while the reliability and reproducibility of the mixing operation are greatly improved.
An all-liquid bone cement product free of reinforcing fillers and consisting of a plurality of liquid components in separate containers to be mixed and reacted together with only limited exposure to air to produce a polymerized bone cement;
An all-liquid bone cement product free of reinforcing fillers and consisting of a plurality of liquid components in separate containers to be mixed and reacted together with only limited exposure to air to produce a polymerized bone cement;
An all-liquid bone cement product free of reinforcing fillers and consisting of at least two liquid components in separate containers to be mixed and reacted together with limited exposure to air to produce a polymerized bone cement;
A method of making bone cement comprising the step of mixing together a plurality of premixed liquid components, each free of reinforcing fillers, under substantially air-free conditions to prevent air entrapment and avoid porosity in the resulting cement;
A method for making bone cement, comprising the steps of preparing a first liquid solution by completely dissolving a linear polymer or copolymer of methyl methacrylate in a non-crosslinking methyl methacrylate monomer, along with a polymerization activator and a polymerization inhibitor, to provide a first liquid premix, free of reinforcing fillers, in which the weight/volume ratio of polymer to monomer is in the range of about 0.5:1 to 2:1 g/ml;
Dependencies are inferred from the claim text.