# US 5,902,789 A · Nasal administration of drugs

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- Number: US 5,902,789 A
- Document ID: US5902789A
- Status: Granted
- Kind: A
- Application number: 08/451,137
- Filed: 1995-05-26
- Granted: 1999-05-11
- Earliest claimed: 1986-04-23
- Assignees: Fisons Limited
- Inventors: Edwin I. Stoltz
- Web page: https://patentgrep.com/patent/US5902789A

## CPC

- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 9/0043: {Nose}
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Compositions and methods for the nasal administration of drugs with reduced nasal irritation are disclosed.

## Claims

### Claim 1

A method for intranasal administration of insulin with reduced nasal irritation which comprises administering a composition consisting essentially of a pharmaceutically effective amount of insulin, polysorbate-80 and nonoxynol-9 at a pH of between 6.8 to 7.2, and wherein the polysorbate-80 is at a concentration of between 0.01 to 0.5% by weight and the nonoxynol-9 is at a concentration of between 0.05 to 0.9% by weight.

### Claim 2 (depends on 1)

A method according to claim 1 where the polysorbate-80 and nonoxynol-9 are present in a ratio of 10:90, weight:weight.

### Claim 3 (depends on 1)

A method according to claim 1 where the polysorbate-80 and nonoxynol-9 are present in a ratio of 25:75, weight:weight.

### Claim 4 (depends on 1)

A method according to claim 1 where the polysorbate-80 and nonoxynol-9 are present in a ratio of 50:50, weight:weight.

### Claim 5 (depends on 1)

A method according to claim 1 wherein the polysorbate-80 is at a concentration of 0.05% by weight and the nonoxynol-9 is at a concentration of 0.45% by weight.

### Claim 6 (depends on 1)

A method according to claim 1 wherein the polysorbate-80 is at a concentration of 0.125% by weight and the nonoxynol-9 is at a concentration of 0.375% by weight.

### Claim 7 (depends on 1)

A method according to claim 1 wherein the polysorbate-80 is at a concentration of 0.25% by weight and the nonoxynol-9 is at a concentration of 0.25% by weight.