Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
AssigneeGlaxo Wellcome Inc.
InventorsSteven Anthony Kliewer, Jurgen M. Lehmann, Timothy M. Willson
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Abstract
The present invention provides activator compounds, including agonists, to the peroxisome proliferator-activated receptor gamma. Particular PPAR.gamma. activators are set forth, as are a pharmaceutical composition for treating diabetes, non-insulin-dependent diabetes mellitus, cardiovascular disorders, and methods for such treatment.
Claims14
A method for identifying compounds which will be useful for the treatment of diabetes, impaired glucose tolerance, obesity, or a cardiovascular disorder, comprising the step of determining whether the compound interacts directly with PPAR-gamma.
A method for identifying compounds which will be useful for the treatment of diabetes, impaired glucose tolerance, obesity, or a cardiovascular disorder, comprising the step of determining whether the compound activates PPAR-gamma.
Dependencies are inferred from the claim text.