US 5,900,436 A · Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them

Abstract

Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: Indanylidineacetylguanidines I ##STR1## and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na.sup.+ /H.sup.+ exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.

Claims15

Dependent claims

An Indanylidineacetylguanidine of formula I ##STR9## wherein, R1, R2, R3, R4, R5 and R6 individually or collectively are H, C.sub.1 -C.sub.10 -alkyl;

haloalkyl having 1-6 carbon atoms, O--C.sub.1 -C.sub.10 -alkyl, haloalkoxy having 1-6 carbon atoms, F, Cl, Br, l, aryl, substituted aryl, OH, O-lower alkyl, O-aryl, O-lower alkyl aryl, O-substituted aryl, O-lower alkyl-substituted aryl, NO.sub.2, CN, CF.sub.3, NH.sub.2, SO.sub.3 H, SO.sub.2 -alkyl or SO.sub.2 -alkylaryl;
X is O:
and
R7, R8, R9 and R10 are hydrogen.

1 more element

Dependencies are inferred from the claim text.

Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them

Life of this patent

Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them

Life of this patent

Abstract

Claims15