US 5,900,245 A · Compliant tissue sealants

Abstract

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

Claims37

Dependent claims

A compliant polymeric material on a tissue surface, wherein the material is formed by

a) contacting the tissue surface with a polymerization initiator,
b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and
c) polymerizing the photopolymerizable groups in an interfacial and bulk manner to form a compliant polymeric material.

Dependencies are inferred from the claim text.

Facts

Application

08/710,689Filed 23 Sep 1996 · continuation in part

Priority

22 Mar 1996

Granted

4 May 1999

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61L 31/06
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61K 9/1647
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers: polyesters, e.g. poly
A61L 24/0042
Use of materials characterised by their function or physical properties: materials resorbable by the body
A61L 24/046
Containing macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Compliant tissue sealants

Life of this patent

Compliant tissue sealants

Life of this patent

Abstract

Claims37