Epichlorohydrin and 1-(3-aminopropyl) imidazole copolymer and its use in treating irritable bowel syndrome
OwnerCharles E. Dayinventor
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Abstract
An anion-binding hydrophilic epichlorohydrin and 1-(3-aminopropyl)imidazole copolymeric bile acid sequestrant, pharmaceutical compositions thereof, and use thereof in the treatment of ailments or conditions in which a bile acid sequestrant and inhibitor of fat absorption is indicated.
Claims11
A composition of matter which is a water-insoluble copolymer of epichlorohydrin and 1-(3-aminopropyl)imidazole, wherein the molar ratio is at least 0.95:1.
A composition comprising a water-insoluble copolymer resulting from a process comprising the steps of:
- mixing 1-(3-aminopropyl)imidazole with water to form a first mixture;
- adding epichlorohydrin to said first mixture to form a second mixture;
- heating said second mixture of 1-(3-aminopropyl)imidazole, water, and epichlorohydrin;
- and
- cooling said heated second mixture.
A process for preparing a water-insoluble copolymer of 1-(3-aminopropyl)imidazole and epichlorohydrin comprising the following steps:
- mixing 1-(3-aminopropyl)imidazole with water to form a first mixture;
- adding epichlorohydrin to said first mixture to form a second mixture wherein the molar ratio of epichlorohydrin to 1-(3-aminopropyl)imidazole is between about 0.95:1 and about 1.5:1;
- heating said second mixture of 1-(3-aminopropyl)imidazole, water, and epichlorohydrin;
- and
- cooling said heated second mixture to produce the desired copolymer.
Dependencies are inferred from the claim text.