Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions
AssigneeAlcon Laboratories, Inc.
InventorsNissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park, Bahram Asgharian
Life of this patent
Estimating the term…
Abstract
N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.
Claims10
A method of disinfecting a contact lens which comprises immersing the lens in an antimicrobial composition for a time sufficient to disinfect the lens, said composition comprising an amount of a compound of the following formula effective to disinfect the lens:
- ##STR3## wherein R is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl or alkoxyaryl;
- R.sup.1 is hydrogen, or C.sub.1 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, alkoxyaryl, or hydroxyalkyl;
- n is 2 to 16;
- and R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable vehicle therefor.
A method of preserving an ophthalmic composition which comprises including in the composition an amount of a compound of the following formula effective to preserve the composition from microbial contamination:
- ##STR4## wherein R is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl or alkoxyaryl;
- R.sup.1 is hydrogen, or C.sub.1 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, alkoxyaryl, or hydroxyalkyl;
- n is 2 to 16;
- and R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof.
A method of cleaning a contact lens which comprises contacting the surfaces of the lens with a composition comprising an amount of a compound of the following formula effective to clean the lens:
- ##STR5## wherein R is C.sub.6 -C.sub.18 saturated or unsaturated alkyl, alkylaryl or alkoxyaryl;
- R.sup.1 is hydrogen, or C.sub.1 -C.sub.18 saturated or unsaturated alkyl, alkylaryl, alkoxyaryl, or hydroxyalkyl;
- n is 2 to 16;
- and R.sup.2 is C.sub.1 -C.sub.8 saturated or unsaturated alkyl or alkanol, or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable vehicle therefor.
Dependencies are inferred from the claim text.