Hetero-linked phenylglycinolamides
AssigneeBayer Aktiengesellschaft
InventorsSiegfried Goldmann, Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Martin Beuck
Life of this patent
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Abstract
The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.
Claims8
Hetero-linked phenylglycinolamides of the general formula (I) ##STR221## in which A represents aryl having 6 to 10 carbon atoms or benzyl, each optionally being substituted up to 3 times identically or differently by halogen, trifluoromethyl, carboxyl, hydroxyl, nitro, cycloalkyl having 3 to 7 carbon atoms, benzyl, phenyl, benzyloxy or by straight-chain or branched alkyl, alkoxy or alkoxycarbonyl each having up to 6 carbon atoms, or a radical of the formula R.sup.5 R.sup.4 N--
- in which
- R.sup.4 and R.sup.5 are identical or different and denote hydrogen, phenyl or straight-chain or branched alkyl having up to 6 carbon atoms,
- D represents a radical of the formula --CO--, --(CO).sub.a --NR.sup.7, --(CH.sub.2).sub.b S--, --(CH.sub.2).sub.c --NR.sup.8 or --CH.dbd.CH--,
- in which
- a, b and c are identical or different and denote a number 0 or 1,
- R.sup.7 and R.sup.8 are identical or different and denote hydrogen, straight-chain or branched alkyl or acyl each having up to 6 carbon atoms, phenyl or benzyl, the ring systems optionally being substituted up to 2 times identically or differently by nitro, halogen, trifluoromethyl or by straight-chain or branched alkyl or alkoxy each having up to 3 carbon atoms,
- E and L are identical or different and represent hydrogen, cycloalkyl having 3 to 8 carbon atoms, azido, hydroxyl, halogen, straight-chain or branched alkyl, alkoxy or alkenyl each having up to 6 carbon atoms,
- R.sup.1 represents cycloalkyl having 3 to 8 carbon atoms, or represents straight-chain or branched allyl having up to 10 carbon atoms,
- R.sup.2 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms,
- R.sup.3 represents a radical of the formula ##STR222## in which R.sup.9 denotes hydrogen or a radical of the formula CH.sub.2 --OH,
- R.sup.10 denotes phenyl which is optionally substituted up to 3 times identically or differently by hydroxyl, halogen or straight-chain or branched alkyl having up to 5 carbon atoms,
- and their salts.
Dependencies are inferred from the claim text.