Compositions for cytochrome P450 biotransformation reactions
AssigneePanVera Corporation
InventorsPeter M. Shaw, Robert G. Lowery, David V. Thompson
Life of this patent
Estimating the term…
Abstract
A storable biotransformation mixture that can oxidize a drug, comprising a cytochrome P450 enzyme, an electron donor; and, a buffer solution. In a preferred embodiment the mixture also contains liposomes, cytochrome b.sub.5 and NADPH-P450 reductase as the electron donor. The mixture is storable at a temperature less than 8.degree. C. to for at least two weeks and is able to oxidize a drug after storage.
Claims22
A biotransformation mixture that can be stored at a temperature less than 8.degree. C. for at least two weeks and is able to oxidize a drug after storage, comprising:
- a) a cytochrome P450 enzyme;
- b) an electron donor;
- c) a lipid;
- and,
- d) a buffer solution.
A biotransformation mixture that may be frozen at a temperature less than 0.degree. C. and is able to oxidize a drug upon thawing, comprising:
- a) a cytochrome P450 enzyme;
- b) an electron donor;
- c) a lipid;
- and,
- d) a buffer solution.
Dependencies are inferred from the claim text.