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US 5,889,038 AGranted
Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
AssigneeChildren's Hospital, Inc.
InventorsWayne I. Lencer, Carlo Brugnara, Seth Alper
Life of this patent
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Abstract
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
Claims29
A method for treating diarrhea or scours, the method comprising the step of:
- administering to a subject in need of such treatment, an aromatic compound in an amount effective to inhibit the diarrhea, the aromatic compound having the general formula:
- ##STR6## wherein n=0-3;
- wherein p=0 or 1;
- wherein X is selected from the group consisting of (CH.sub.2).sub.m (m=0,1,2, or 3), CH.dbd.CH, C.tbd.C, SCH.sub.2, OCH.sub.2, and NOCH.sub.2 ;
- wherein R' is selected from the group consisting of H, OH, SH, NO.sub.2, CN, CHO, ONH.sub.2, CCH, COR", CO.sub.2 H, CO.sub.2 R", OR", SR", NR"R", CONR"R", heteroaryl, and CONR"(OCH.sub.3);
- wherein Ar.sup.1 is selected from the group consisting of phenyl, substituted phenyl, and heteroaryl;
- wherein Ar.sup.2 is selected from the group consisting of phenyl and substituted phenyl;
- wherein Ar.sup.3 is selected from the group consisting of phenyl, substituted phenyl, biphenyl, bibenzyl, and naphthyl;
- wherein the phenyl substituent is selected from the group consisting of Cl, F, Br, I, R, OR", SR", NO.sub.2, CN, CF.sub.3, NR"R", and CO.sub.2 R;
- wherein R is selected from the group consisting of straight chain alkyl of C.sub.z(z=1-5), substituted straight chain alkyl of C.sub.z(z=1-5) branched alkyl of C.sub.z(z=1-5), and substituted branched alkyl of C.sub.z(z=1-5) ;
- wherein the alkyl substituent is selected from the group consisting of Cl, Br, F, I, OH, OCH.sub.3, SH, SCH.sub.3, NH.sub.2, NHCH.sub.3, and N(CH.sub.3).sub.2 ;
- and wherein R" is selected from the group consisting of hydrogen and R.
9 more elements
A veterinary preparation comprising:
- an aromatic compound in an amount effective to inhibit scours in a subject, the aromatic compound having the general formula:
- ##STR9## wherein n=0-3;
- wherein p=0 or 1;
- wherein X is selected from the group consisting of (CH.sub.2).sub.m (m=0,1,2, or 3), CH.dbd.CH, C.tbd.C, SCH.sub.2, OCH.sub.2, and NOCH.sub.2 ;
- wherein R' is selected from the group consisting of H, OH, SH, NO.sub.2, CN, CHO, ONH.sub.2, CCH, COR", CO.sub.2 H, CO.sub.2 R", OR", SR", NR"R", CONR"R", heteroaryl, and CONR"(OCH.sub.3);
- wherein Ar.sup.1 is selected from the group consisting of phenyl, substituted phenyl, and heteroaryl;
- wherein Ar.sup.2 is selected from the group consisting of phenyl and substituted phenyl;
- wherein Ar.sup.3 is selected from the group consisting of phenyl, substituted phenyl, biphenyl, bibenzyl, and naphthyl;
- wherein the phenyl substituent is selected from the group consisting of Cl, F, Br, I, R, OR", SR", NO.sub.2, CN, CF.sub.3, NR"R", and CO.sub.2 R;
- wherein R is selected from the group consisting of straight chain alkyl of C.sub.z(z=1-5), substituted straight chain alkyl of C.sub.z(z=1-5), branched alkyl of C.sub.z(z=1-5), and substituted branched alkyl of C.sub.z(z=1-5) ;
- wherein the alkyl substituent is selected from the group consisting of Cl, Br, F, I, OH, OCH.sub.3, SH, SCH.sub.3, NH.sub.2, NHCH.sub.3, and N(CH.sub.3).sub.2 ;
- and wherein R" is selected from the group consisting of hydrogen and R;
- and,
- an anti-scours agent.
11 more elements
A pharmaceutical preparation, comprising:
- an aromatic compound in an amount effective to inhibit diarrhea, the aromatic compound having the general formula:
- ##STR11## wherein n=0-3;
- wherein p=0 or 1;
- wherein X is selected from the group consisting of (CH.sub.2).sub.m (m=1,2 or 3), CH.dbd.CH, C.tbd.C, SCH.sub.2, OCH.sub.2, and NOCH.sub.2 ;
- wherein R' is selected from the group consisting of H, OH, SH, NO.sub.2, CN, CHO, ONH.sub.2, CCH, COR", CO.sub.2 H, CO.sub.2 R", OR", SR", NR"R", CONR"R", heteroaryl, and CONR"(OCH.sub.3);
- wherein Ar.sup.1 is selected from the group consisting of phenyl, substituted phenyl, and heteroaryl;
- wherein Ar.sup.2 is selected from the group consisting of phenyl and substituted phenyl;
- wherein Ar.sup.3 is selected from the group consisting of phenyl, substituted phenyl, biphenyl, bibenzyl, and naphthyl;
- wherein the phenyl substituent is selected from the group consisting of Cl, F, Br, I, R, OR", SR", NO.sub.2, CN, CF.sub.3, NR"R", and CO.sub.2 R;
- wherein R is selected from the group consisting of straight chain alkyl of C.sub.z(z=1-5), substituted straight chain alkyl of C.sub.z(z=1-5), branched alkyl of C.sub.z(z=1-5), and substituted branched alkyl of C.sub.z(z=1-5) ;
- wherein the alkyl substituent is selected from the group consisting of Cl, Br, F, I, OH, OCH.sub.3, SH, SCH.sub.3, NH.sub.2, NHCH.sub.3, and N(CH.sub.3).sub.2 ;
- and wherein R" is selected from the group consisting of hydrogen and R;
- and,
- an anti-diarrheal agent.
11 more elements
A method for treating diarrhea or scours, the method comprising the step of:
- administering to a subject in need of such treatment, an aromatic compound in an amount effective to inhibit diarrhea, the aromatic compound selected from the group consisting of miconazole and econazole.
Dependencies are inferred from the claim text.