Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
AssigneeDermal Research Laboratories, Inc.
InventorHarold G. Brown
Life of this patent
Estimating the term…
Abstract
The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.
Claims65
A topical pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and at least one essential oil in an amount effective to allow penetration of the dermis of mammals by the complex carbohydrate.
A pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides, and glycosaminoglycans and at least one essential oil in an amount effective to allow penetration of the dermis of mammals by the complex carbohydrate.
A topical pharmaceutical composition which consists essentially of as an active ingredient a pharmacologically effective amount of at least one complex carbohydrate selected from the group consisting of a mixture of high and low molecular weight ranges of low purity or cosmetic grade hyaluronic acid in a total concentration of between 0.5% and 3.0% wt/vol and at least one essential oil selected from the group consisting of Tea Tree Oil, Rosemary Oil, Peppermint Oil and Wintergreen Oil in a total concentration of between 0.5% and 3.0% vol/vol.
A method of inhibiting the inflammatory process by introducing a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, which is biospecific for the adhesion cascade and blocks the binding of leucocytes to the epithelium during migration and extravasation of leucocytes to a site of trauma.
A method for inhibiting inflammation which comprises providing a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and which inhibits the adhesion cascade so as to inhibit binding of leucocytes to epithelium, mixing said compound with an essential oil to obtain a mixture, and applying said mixture to a site in need of treatment to inhibit inflammation.
A topical pharmaceutical composition consisting essentially of as an active ingredient a pharmacologically effective amount of at least one low purity or cosmetic grade complex carbohydrate selected from the group consisting of oligosaccharides, sialylated oligosaccharides, polysaccharides and glycosaminoglycans, and at least one essential oil in an amount effective to allow penetration of the dermis of mammals by the complex carbohydrate.
A composition for topically treating inflammation, pain or itching, comprising a pharmaceutically effective amount of a low purity or cosmetic grade glycosaminoglycan or mannan in combination with an essential oil present in an amount effective to allow penetration of the dermis of mammals by the glycosaminoglycan or mannan.
A method of treating pain and inflammation comprising topically applying a pharmaceutical composition consisting essentially of a low purity or cosmetic grade glycosaminoglycan or mannan combined with an essential oil present in an amount effective to allow penetration of the dermis of mammals by the glycosaminoglycan or mannan.
Dependencies are inferred from the claim text.