Regulation of vascular smooth muscle cell heme oxygenase-1
AssigneePresident and Fellows of Harvard College
InventorsMark A. Perrella, Mu-En Lee
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Abstract
The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.
Claims2
A method of inhibiting sepsis-associated hypotension in a mammal, said method comprising identifying a mammal with or at risk of developing sepsis and administering to said mammal a compound which inhibits expression of inducible heme oxygenase (HO-1), wherein said compound inhibits translation of HO-1 mRNA in a vascular cell of said mammal.
Dependencies are inferred from the claim text.