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US 5,888,533 AGranted
Non-polymeric sustained release delivery system
AssigneeAtrix Laboratories, Inc.
InventorRichard L. Dunn
Life of this patent
Estimating the term…
Abstract
The invention relates to a method and composition for forming an implant in-situ within a body using non-polymeric materials, and the use of such implants as medical devices and drug delivery systems. The composition can be applied to an animal to treat periodontal disease or other tissue defect, enhance compatibility and performance of an implantable article, and deliver a biologically active agent.
Claims30
A flowable composition for forming a solid biodegradable implant in situ within a body, comprising:
- (a) a non-polymeric, water-insoluble material that is biodegradable;
- and
- (b) a biocompatible, organic solvent that at least partially solubilizes the non-polymeric, water-insoluble material and is miscible to dispersible in water or body fluids, and capable of dissipating, diffusing or leaching from the composition into body fluid upon placement within a body, whereupon the non-polymeric material coagulates or precipitates to form the solid implant.
A non-polymeric system suitable as a controlled release implant, comprising:
- a solid, microporous matrix formed by contact between an aqueous medium and a flowable composition of a water-insoluble, biodegradable, non-polymeric material and a biocompatible, organic solvent that at least partially solubilizes the non-polymeric material, and is miscible to dispersible in water or body fluids, and capable of dissipating, diffusing or leaching from the composition into body fluid upon placement within a body, whereupon the non-polymeric material coagulates or precipitates to from the solid implant.
Dependencies are inferred from the claim text.