Agonist compounds

Abstract

New morphinane derivatives of the formula (I) ##STR1## their pharmaceutically acceptable salts, a process for their preparation and their use in therapy. The variables in the above structure are as follows: R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl and hydrogen; R.sub.2 is selected from the group consisting of hydrogen; hydroxy; C.sub.1 -C.sub.6 alkoxy; C.sub.7 -C.sub.16 arylalkyloxy, wherein the aryl is C.sub.6 -C.sub.10 aryl and the alkyloxy is C.sub.1 -C.sub.6 alkyloxy; R.sub.3 is a C.sub.1 -C.sub.6 alkyl; R.sub.4 is a hydrogen; hydroxy; or a C.sub.1 -C.sub.6 alkoxy; R.sub.5 and R.sub.6 each and independently are selected from the group consisting of hydrogen; and C.sub.1 -C.sub.6 alkyl; X is NR.sub.9, wherein R.sub.9 is selected from the group consisting of hydrogen; and C.sub.1 -C.sub.6 alkyl; and wherein any aryl group in the compound may be unsubstituted or mono-, di-, or tri-substituted independently with hydroxy; halo; nitro; cyano; thiocyanato; trifluoromethyl; C.sub.1 -C.sub.3 alkyl; C.sub.1 -C.sub.3 alkoxy; CO.sub.2 H; CONH.sub.2 ; CO.sub.2 (C.sub.1 -C.sub.3 alkyl); CONH(C.sub.1 -C.sub.3 alkyl); CON(C.sub.1 -C.sub.3 alkyl).sub.2 ; CO(C.sub.1 -C.sub.3 alkyl); amino; (C.sub.1 -C.sub.3 monoalkyl) amino; (C.sub.1 -C.sub.3 dialkyl) amino; C.sub.5 -C.sub.6 cycloalkylamino; (C.sub.1 -C.sub.3 alkanoyl) amido; SH; SO.sub.3 H; SO.sub.3 (C.sub.1 -C.sub.3 alkyl); SO.sub.2 (C.sub.1 -C.sub.3 alkyl); SO(C.sub.1 -C.sub.3 alkyl); C.sub.1 -C.sub.3 alkylthio; and C.sub.1 -C.sub.3 alkanoylthio.

Dependencies are inferred from the claim text.