Aminocyclohexylesters and uses thereof

An enantiomer or geometric isomer of a compound of formula I, or a solvate or pharmaceutically acceptable salt thereof, said compound of the formula:

• ##STR45## wherein X is a direct bond;
• or --(CH.sub.2).sub.n --Y--, where n=1, 2, or 3, and Y is a direct bond, O or S;
• or --CH(R.sub.12)--Y--, where R.sub.12 is alkyl of from one to six carbon atoms, a saturated carbocyclic ring of from three to six carbon atoms, phenyl or benzyl, and Y is a direct bond, O or S;
• or --C(R.sub.13 ).dbd.CH--, where R.sub.13 is hydrogen, alkyl of from one to six carbon atoms, or phenyl;
• R.sub.1 and R.sub.2, taken together with the nitrogen atom to which they are attached, form
• a saturated monoloyclic nitrogen heterocyclic ring of five to eight ring atoms, containing only carbon, nitrogen and oxygen ring atoms, and said heterocyclic ring containing not more than two nitrogen ring atoms, the second nitrogen being optionally substituted with an alkyl group of one to six carbon atoms or a phenyl ring;
• R.sub.3 and R.sub.4 are independently attached to the cyclohexane ring at the 3-, 4-, 5-, or 6-positions, and are independently hydrogen, hydroxy, alkyl of one to six carbon atoms or alkoxy of one to six carbon atoms, or are points of attachment of a spiro five- or six-membered heterocyclic ring containing one oxygen or sulfur atom;
• and
• A is an alkyl group of five to twelve carbon atoms, or is a saturated carbocyclic ring of three to six carbon atoms, or is selected from formulae III, IV, V, VI, VII or VIII:
• ##STR46## where R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen, hydroxy, amino, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, or aryl, and when X is a direct bond at least one of R.sub.5, R.sub.6 and R.sub.7 is a hydroxy, fluorine, chlorine, bromine, trifluoromethyl, alkyl of from one to six carbon atoms, or aryl substituent, and when X is --CH.dbd.CH--, and R.sub.1 and R.sub.2 when taken together with the nitrogen atom to which they are attached, form a N-phenylpiperazine ring, and R.sub.3 and R.sub.4 are hydrogen, at least one of R.sub.5, R.sub.6 and R.sub.7 is a substituent other than hydrogen;
• ##STR47## where R.sub.8 and R.sub.9 hydroxy, fluorine, chlorine, bromine, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms or aryl;
• ##STR48## where R.sub.8 and R.sub.9 are define as above;
• ##STR49## where R.sub.10 is hydrogen, hydroxy, fluorine, chlorine, bromine, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms or aryl;
• Z is CH.sub.2, O, S, or N--R.sub.11 where R.sub.11 is hydrogen or alkyl of one to six carbon atoms;
• ##STR50## only when X is a direct bond;
• ##STR51## only when X is a direct bond.