CTLA4 receptor and uses thereof
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, William Brady
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Abstract
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
Claims12
An isolated CTLA4 receptor protein having the amino acid sequence depicted in FIG. 3 (SEQ ID NO:
- 14).
A DNA sequence encoding the amino acid sequence corresponding to CTLA4Ig fusion protein reactive with B7 antigen and having ATCC No. 68629.
A purified soluble CTLA4 protein comprising the 125 amino acids shown in SEQ ID NO:
- 14 beginning with alanine at position 1 and ending with asparagine at position 125 of the amino acid sequence of the extracellular domain of the CTLA4 protein.
A purified, soluble CTLA4 protein which binds a B7 antigen expressed on activated B cells, comprising the 187 amino acids shown in SEQ ID NO:
- 14 beginning with alanine at position 1 and ending with asparagine at position 187.
Dependencies are inferred from the claim text.