Empty canine parvovirus capsids having CPV recombinant VP2 and vaccines having such capsids
AssigneeImmunologia Y Genetica Aplicada, S.A.
InventorsElena Cortes Valdes, Carmen Vela Olmo, Jose Ignacio Casal Alvarez
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Abstract
The present invention is a method for the production of a subunit vaccine against canine parvovirus (CPV). The method includes the step wherein a recombinant protein VP2 of CPV is obtained by using the replication of a recombinant baculovirus wherein the gene corresponding to VP2 has been previously inserted in cells of a permissive host. The protein VP2 obtained has the capacity of forming empty VP2 capsids with high immunogenicity and can be provided as a vaccine formulation for protecting dogs against CPV infection the recombinant baculovirus AcMNPV.pCPVEx17 expresses the VP2 of CPV in conditions making possible the formulation of pseudo-viral capsids.
Claims2
A recombinant subunit vaccine for protecting dogs from canine parvovirus (CPV) infection comprising:
- an immunizing quantity of isolated empty CPV capsids each consisting of autoassembled CPV recombinant VP2 protein;
- and
- a diluent and an adjuvant.
A method for protecting dogs from infection caused by canine parvovirus (CPV) comprising the step of:
- administering to a dog a protective dosage of a vaccine of isolated empty CPV capsids each consisting of an autoassembled recombinant VP2 protein, said vaccine also containing a diluent and an adjuvant.
Dependencies are inferred from the claim text.