Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use

A compound of formula (I):

• ##STR19## wherein:
• R.sup.1 represents an alkyl group having from 1 to 12 carbon atoms;
• R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each represents:
• a hydrogen atom;
• an alkyl group having from 1 to 12 carbon atoms;
• an alkyl group which has from 1 to 4 carbon atoms and which is substituted by from 1 to 5 fluorine atoms;
• an alkyl group which has from 1 to 12 carbon atoms and which is substituted by an unprotected or protected hydroxy group;
• a group of formula --(C.dbd.O)--B.sup.1
• wherein B.sup.1 represents a hydrogen atom, or an alkyl group having from 1 to 12 carbon atoms,
• a nitro group;
• a group of formula --NR.sup.c R.sup.d
• wherein R.sup.c represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.d represents an alkyl group having from 1 to 4 carbon atoms;
• a hydroxy group or a protected hydroxy group;
• an alkoxy group having from 1 to 10 carbon atoms;
• a cyano group;
• an alkylthio group having from 1 to 6 carbon atoms;
• an alkylsulfinyl group having from 1 to 6 carbon atoms;
• an alkylsulfonyl group having from 1 to 6 carbon atoms;
• or a halogen atom;
• or
• R.sup.2a and R.sup.2b are adjacent to each other and together represent a group of formula
• --O--(CH.sub.2).sub.m --O--
• wherein m is an integer of from 1 to 3;
• R.sup.3 represents an alkyl group having from 1 to 6 carbon atoms;
• R.sup.4 represents a group of formula (II):
• ##STR20## wherein:
• A.sup.1 represents a single bond, an alkylene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;
• R.sup.5a and R.sup.5b are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a group of formula --A.sup.4 R.sup.5c
• wherein A.sup.4 represents a single bond, an alkylene group having from 1 to 6 carbon atoms or an alkenylene group having from 2 to 6 carbon atoms;
• R.sup.5c represents an alkoxy group having from 1 to 4 carbon atoms and
• n represents 0,
• and pharmaceutically acceptable salts thereof.