Human transaldolase: an autoantigen with a function in metabolism
AssigneeThe Research Foundation of State University of New York
InventorAndras Perl
Life of this patent
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Abstract
Transaldolase is an enzyme which acts as an autoantigen in immune-related neurodegenerative diseases, particularly multiple sclerosis. Human transaldolase, the DNA coding therefore, peptides derived therefrom, and DNA control elements associated therewith and anti-transaldolase antibodies are disclosed. These compositions are useful in methods such as immunoassays for detecting subjects making anti-transaldolase antibodies and diagnosing the neurodegenerative disease.
Claims14
An isolated DNA molecule encoding (i) a human tansaldolase protein molecule SEQ ID NO:2, (ii) a peptide fragment thereof or (iii) a functional derivative thereof, or an allelic variant of said transaldolase-encoding DNA molecule,
- which peptide fragment or functional derivative comprises one or more T cell epitopes or one or more B cell/antibody epitopes,
- with the proviso that said DNA molecule is not:
- (a) an oligonucleotide of 18 nucleotides encoding Thr-Leu-Leu-Phe-Ser-Phe;
- Tyr-Asn-Tyr-Tyr-Lys-Lys;
- or Ala-Asn-Thr-Asp-Lys-Lys;
- (b) an oligonucleotide of 21 nucleotides encoding Asp-Arg-Ile-Leu-Ile-Lys-Leu;
- Thr-Thr-Val-Val-Ala-Asp-Thr;
- or Ala-Cys-Ala-Glu-Ala-Gly-Val;
- (c) an oligonucleotide of 24 nucleotides encoding Gln-Ala-Val-Ala-Cys-Ala-Glu-Ala;
- or Val-Val-Ala-Asp-Thr-Gly-Asp-Phe;
- (d) an oligonucleotide of 27 nucleotides encoding Thr-Thr-Val-Val-Ala-Asp-Thr-Gly-Asp;
- Thr-Leu-Leu-Phe-Ser-Phe-Ala-Gln-Ala;
- or Ser-Thr-Glu-Val-Asp-Ala-Arg-Leu-Ser;
- (e) an oligonucleotide of 33 nucleotides encoding Tyr-Lys-Thr-Ile-Val-Met-Gly-Ala-Ser-Phe-Arg;
- or Thr-Thr-Asn-Pro-Ser-Leu-Ile-Leu-Ala-Ala-Ala;
- (f) an oligonucleotide of 36 nucleotides encoding Pro-Gln-Asp-Ala-Thr-Thr-Asn-Pro-Ser-Leu-Ile-Leu;
- or Leu-Ile-Ser-Pro-Phe-Val-Gly-Arg-Ile-Leu-Asp-Trp;
- (g) an oligonucleotide of 42 nucleotides encoding Val-Thr-Leu-Ile-Ser-Pro-Phe-Val-Gly-Arg-Ile-Leu-Asp-Trp;
- or Gly-Arg-Val-Ser-Thr-Glu-Val-Asp-Ala-Arg-Leu-Ser-Phe-Asp;
- or
- (h) an oligonucleotide of 45 nucleotides encoding Pro-Gly-Arg-Val-Ser-Thr-Glu-Val-Asp-Ala-Arg-Leu-Ser-Phe-Asp;
- and which DNA molecule is substantially free of other human DNA molecules with which it is natively associated.
Dependencies are inferred from the claim text.