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US 5,877,224 AGranted
Polymeric drug formulations
AssigneeRutgers, The State University of New Jersey
InventorsStephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
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AssigneeRutgers, The State University of New Jersey
InventorsStephen Brocchini, Stephen R. Hanson, Joachim B. Kohn
Estimating the term…
Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.
A polymeric drug formulation comprising a single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix, and a water-soluble poly(alkylene oxide) that is present in an amount effective to increase the release rate of said water-soluble drug from said tissue-compatible polymer matrix.
A blood-contacting device or implant coated with a polymeric drug formulation comprising a single-phase dispersion of a platelet aggregation inhibiting peptide in a water-insoluble tissue-compatible polymer matrix and a water-soluble poly(alkylene oxide) that is present in an amount effective to increase the release rate of said peptide from said tissue-compatible polymer matrix.
Dependencies are inferred from the claim text.