Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsYaacov Herzig, Jeff Sterling, Alex Veinberg, Benjamin Sklarz, Ramy Lidor, Eliezer Bahar
Life of this patent
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Abstract
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, convulsions, or seizures are treated by administering a compound of the formula: ##STR1##
Claims19
A compound selected from the group consisting of (S)-N-formyl-1-aminoindan, (R)-N-acetyl-1-aminoindan, N-acetyl-7-methyl-1-aminoindan, N-acetyl-6-fluoro-1-aminoindan, (R)-N-acetyl-6-fluoro-1-aminoindan, (S)-N-acetyl-6-fluoro-1-aminoindan, N-acetyl-6-methoxy-1-aminoindan, (R)-N-acetyl-6-methoxy-1-amninoindan, (S)-N-acetyl-6-methoxy-1-aminoindan, N-acetyl-4,5,-dimethoxy-1-aminoindan, (R)-Nacetyl-4,5-dimethoxy-1-aminoindan, (S)-N-acetyl-4,5-dimethoxy-1-aminoindan, N-(2-phenylacetyl)-1-aminoindan, N-(m-anisoyl)-1-aminoindan, N -(4'-fluorobenzoyl)-1-aminioindan, N-(p-toluoyl)-1-aminoindan, N-(4-aminobutanoyl)-1-aminoindan, N-(2-acetamido)-1-aminoindan, (R)-N-(2-acetamido)-1-aminoindan, (S)-N-(2-acetamido)-1-aminoindan, N-(2-acetamido)-6-fluoro-1-aminoindan, N-(3-cyanopropyl)-1-aminoindan, N-(2-N-Boc-aminoacetyl)-1-aminoindan, N-(2-aminoacetyl)-1-aminoindan, N-(2-n-propylpentanoyl)-1-aminoindan, N-(4-di-n-propylsulfamoyl) benzoyl-1-aminoindan, N-(2-propionamido)-1-aminoindan, N-N-di-(2-acetamido)-1-aminoindan, N-(1-indanyl)amino-acetonitrile, 2-(1-indanamino)-N-isoprpopylethane-sulfonamide, 2-(1-indanamino)-N-(1-indanyl) ethane-sulfonamide, (R,R)-2-(1-indanamino)-N-(1-indanyl) ethanesulfonamide, N-N'-bis-(1-indanyl) adipamide, N-N'-bis-(R)-(1-indanyl)adipamide, N-N'-bis-(R)-(1-indanyl)succinamide, and salts thereof.
R-(+)-N-benzyl-1-aminoindan.
R-(+)-N-benzyl-1-aminoindan-L-mandelate ethanolate.
S-(-)-N-benzyl-1-aminoindan-D-mandelate ethanolate.
Dependencies are inferred from the claim text.