Back to results
US 5,877,214 AGranted
Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis
AssigneeMerck & Co., Inc.
InventorRonald M. Kim
Life of this patent
Estimating the term…
Abstract
The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ("polyaryl-PEG" compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.
Claims20
A compound of the Formula I, II or III:
- ##STR29## wherein:
- A, A', A" and A'" are independently selected from:
- ##STR30## X and X' are independently selected from the group consisting of:
- --OH, --Br, --Cl, --I, --SH, --CO.sub.2 H, --CO.sub.2 Cl, CO.sub.2 Br, --SO.sub.3 H, --SO.sub.2 Cl, --NH.sub.2, and --CH=CH.sub.2 ;
- Y is independently selected from the group consisting of:
- hydrogen, --CH.sub.3, --O--(C.sub.1-6 alkyl) and --O(CH.sub.2 CH.sub.2 O).sub.n --CH.sub.3 ;
- j and j' are independently an integer from 0 to 4, inclusive;
- k and k' are independently an integer from 1 to 12, inclusive;
- m and m' are independently an integer from 1 to 4, inclusive;
- and
- n is an integer from 0 to 12, inclusive;
- and salts thereof.
9 more elements
A compound which is selected from the group consisting of:
- ##STR31##
Dependencies are inferred from the claim text.