Substituted biphenyl compounds

A Compound selected from those of formula (I) ##STR46## wherein:

• R.sub.1 represents substituted or unsubstituted (C.sub.3 -C.sub.7)-cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted naphthyl, a saturated or unsaturated substituted or unsubstituted mono- or bi-cyclic heterocyclic group containing 1 to 3 hetero atoms inclusive selected from nitrogen, oxygen, and sulphur, a linear or branched substituted or unsubstituted (C.sub.1 -C.sub.6)-alkyl, or a linear or branched substituted or unsubstituted (C.sub.1 C.sub.6)-alkenyl;
• A represents a bond (with the proviso that in that case R.sub.1 is other than C.sub.1 - or C.sub.2 -alkyl), oxygen, sulphur, a group ##STR47## a group, ##STR48## or a group ##STR49## (wherein Rc represents hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, or (C.sub.3 -C.sub.7)-cycloalkyl),
• R.sub.2 represents halogen, linear or branched substituted or unsubstituted (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.6) alkylcarbonyl, a linear or branched substituted or unsubstituted (C.sub.1 -C.sub.6)-alkenyl, a linear or branched substituted or unsubstituted (C.sub.1 -C.sub.6)-alkynyl, substituted or unsubstituted (C.sub.3 -C.sub.7)-cycloalkyl, (C.sub.3 -C.sub.7)-cycloalkylcarbonyl, formyl, carboxy, linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl, (C.sub.3 -C.sub.7)-cycloalkyloxycarbonyl, carbamoyl (optionally substituted by one or two groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)-alkoxy, and (C.sub.3 -C.sub.7)-cycloalkoxy, or forming together with the nitrogen atom of the carbamoyl carrying them a 5 to 7 member ring containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), amino (optionally substituted by one or two groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl, linear or branched (C.sub.1 -C.sub.6)-acyl, and (C.sub.3 -C.sub.7)-cycloalkyl, or forming together with the nitrogen atom of the amino carrying them a 5 to 7 member ring containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), formylamino, cyano, amidino (optionally substituted by one or two groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl and (C.sub.3 -C.sub.7)-cycloalkyl, or forming together with the nitrogen atom of the amidino carrying them a 5 to 7 member ring containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), hydroxyaminomethyl (optionally substituted, independently on the nitrogen or oxygen, by linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, or linear or branched (C.sub.1 -C.sub.6)-acyl), amnide oxime (optionally substituted, independently on the nitrogen or oxygen, by linear or branched (C.sub.1 -C.sub.6)-alkyl or (C.sub.3 -C.sub.7)-cycloalkyl, or forming together with the nitrogen atom carrying them a 5 to 7 member ring containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), hydrazono (optionally substituted by one or two groups selected from linear or branched (C.sub.1 -C.sub.6)-alkyl and (C.sub.3 -C.sub.7)-cycloalkyl, or forming together with the nitrogen atom carrying them a 5 to 7 member ring containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), or a group selected from:
• ##STR50## wherein:
• R.sub.21 represents hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, or (C.sub.3 -C.sub.7)-cycloalkyl,
• R.sub.22 represents hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, or linear or branched (C.sub.1 -C.sub.6)-acyl,
• R.sub.23 represents linear or branched (C.sub.1 -C.sub.6)-alkyl or (C.sub.3 -C.sub.7)-cycloalkyl,
• R.sub.3 represents hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, or linear or branched (C.sub.1 -C.sub.6)-acyl, or ##STR51## together form the ring ##STR52## wherein X represents oxygen, sulphur or NR" (in which R" represents hydrogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.7)-cycloalkyl, or linear or branched (C.sub.1 -C.sub.6)-acyl),
• the ring B is phenyl,
• Ra and Rb, which may be identical or different, each represents hydrogen, halogen, linear or branched (C.sub.1 -C.sub.6)-alkyl, hydroxy, linear or branched (C.sub.1 -C.sub.6)-alkoxy, carboxy, linear or branched (C.sub.1 -C.sub.6)-polyhalogenoalkyl, cyano, nitro, linear or branched (C.sub.1 -C.sub.6)-alkoxycarbonyl, (C.sub.3 -C.sub.7)-cycloalkyloxycarbonyl, amino (optionally substituted by one or two linear or branched (C.sub.1 C.sub.6)-alkyl, linear or branched (C.sub.1 C.sub.6)-acyl, or (C.sub.3 -C.sub.7)-cycloalkyl), (C.sub.3 -C.sub.7)-cycloalkyl, or linear or branched (C.sub.1 -C.sub.6)-alkoxy), sulfo, linear or branched (C.sub.1 -C.sub.6)-alkylsulfonyl, or aminosulfonyl (optionally substituted by one on two linear or branched (C.sub.1 -C.sub.6)-alkyl or (C.sub.3 -C.sub.7)-cycloalkyl),
• with the proviso that
• when A represents a bond or oxygen, B represents phenyl, R.sub.1 represents substituted or unsubstituted (C.sub.3 -C.sub.7)-cycloalkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted naphthyl, X represents oxygen or NR" (in which R" represents hydrogen or linear or branched (C.sub.1 -C.sub.6)-alkyl) and R.sub.3 represents hydrogen or linear or branched (C.sub.1 -C.sub.6)-alkyl, then R.sub.2 is other than carboxy,
• their isomers and the addition salts thereof with a pharmaceutically-acceptable acid or base.