Fusion polypeptides comprising human serum albumin, nucleic acids encoding same, and recombinant expression thereof
OwnerReinhard Fleer, Alain Fournier +3inventors
InventorsReinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
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Abstract
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a natural variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
Claims15
A fusion polypeptide comprising human serum albumin or a natural variant thereof and a separate, heterologous therapeutically active polypeptide attached to each of the C-terminal end and the N-terminal end of said human serum albumin.
Dependencies are inferred from the claim text.