Biocompatible adhesion in tissue repair

A wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and, optionally, fluoride, that has been coated on an adhesive receptive surface and cured prior to application.

A process for the treatment of a wound which comprises applying a wound dressing comprising a primary coating that comprises a hydrophilic water insoluble crosslinked resin and leachable fluoride dispersed therein onto an injured portion of a mammalian body, and allowing the fluoride to be released from the primary coating to contact and penetrate the injured area.

In a non-dental-related surgical process wherein a repair is made by adhering one or more bones and/or prosthetic devices to each other and to any contacting soft tissue, the improvement being that the adherence of said bone(s) and/or prosthetic device(s) is accomplished by applying a primary coating comprising a hydrophilic water insoluble crosslinked resin containing both hard and soft crosslinkers and, optionally, fluoride, to one or more of the surfaces of the bone(s) or prosthetic device(s).

In a non-dental-related process for aiding in the healing of an open wound or an exposed wound, the improvement which comprises superimposing a cured layer of a primary coating comprising a hydrophilic water insoluble crosslinked resin and fluoride onto the wound such that the tissues at the wound surface are in direct contact with the layer, and maintaining contact between the layer and the wound at least until such time as the wound is essentially closed as a result of the healing process.

A non-dental-related process for repairing an injured or degenerated osseous material which comprises superimposing a patch of a cured layer of a primer coating comprising a hydrophilic water insoluble crosslinked resin with fluoride onto the injured or degenerated area of the osseous material, leaving such patch in contact with the area and allowing growth of the osseous material to encompass the patch and repair the injured or degenerated area.

A process for enhancing the normal healing processes of injured non-dental-related soft tissue and non-dental-related osseous material, that involves placing at the injury a primary coating that is a hydrophilic water insoluble crosslinked resin coating that optionally contains a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.

A process for enhancing the biocompatibility and adhesion of bone and/or prosthetic devices involved in a non-dental procedure to tissue components with which they are in contact and wherein there is an injury, that involves placing at the injury or on the prosthesis a primary coating that is a hydrophilic water insoluble crosslinked resin coating containing both hard and soft crosslinkers and, optionally, a measurable amount of a water/fluid leachable fluoride capable of (a) being leached from the coating in a metered amount, and (b) transporting a small amount of leached fluoride from the coating into the afflicted area.