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AssigneeBoard of Regents, The University of Texas System
InventorsC. Mauli Agrawal, Robert C. Schenck
Estimating the term…
Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a biodegradable carrier, such as a biodegradable polymer. The pores or intersticial spaces of the tissue-mating surface of the device are impregnated with the biodegradable polymer. The prosthesis of the present invention provides for enhanced rigid fixation, as pores at the surface of said device provide for bony ingrowth as the biodegradable carrier, i.e., polymer, degrades. Methods for preparing said prosthesis are described. Methods for delivering a pharmacologically active substance by including a pharmacologically active substance in the biodegradable carrier (e.g., polymer) are also disclosed.
A metallic press fit prosthetic device comprising at least one porous tissue mating surface on said metallic press fit prosthetic device having interstitial spaces impregnated with a polymer selected from a group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa and said polymer further containing a pharmacologically active substance, wherein release of said substance at the surface is controlled over a therapeutically effective period of time, when said device is implanted in a patient.
A method of delivering a pharmacologically active agent comprising implanting into an animal a metallic press-fit prosthetic device comprising at least one microporous tissue mating surface having interstitial spaces impregnated with a polymer selected from the group consisting of PLA, PGA, and PLA-PGA copolymer, said polymer having a molecular weight of about 40 to 100,000 kDa, said polymer further comprising a pharmacologically active agent.
Dependencies are inferred from the claim text.