Ruthenium catalysts and their use in the asymmetric hydrogenation of cyclopentenones
AssigneeFirmenich SA
InventorsValentin Rautenstrauch, Koenraad P. M. Vanhessche, Jean-Pierre Genet, Jean-Yves Lenoir
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Abstract
A catalyst of ruthenium (II) which includes bidentate phosphine ligands. The catalyst is obtainable by a process which includes the steps of treating equimolar amounts of an appropriate Ru(II) complex and a bidentate diphosphine ligand with an acid of formula HX, wherein X is a non-coordinating anion. The acid is used in a ratio which does not exceed 2 molar equivalents per mole of Ru(II) complex and the treatment is carried out in a non-coordinating or weakly coordinating solvent and under an inert atmosphere. This catalyst is useful for the preparation of the preferred isomer of HEDIONE, having the (+)-(1R)-cis-configuration.
Claims26
Ruthenium (II) catalyst comprising ligands formed of bidentate phosphines, characterized in that it is obtainable by a process which comprises treating an appropriate Ru(II) complex and a bidentate diphosphine ligand, present in equimolar amounts, with an acid of formula HX, wherein X is a non-coordinating anion, said acid being used in a ratio which does not exceed 2 molar equivalents per mole of the Ru(II) complex, the treatment being carried out in a non-coordinating or weakly coordinating medium and under an inert atmosphere.
Process for the preparation of a catalyst of Ru(II), characterized in that equimolar amounts of an appropriate Ru(II) complex and of a bidentate phosphine ligand are reacted, under an inert atmosphere and in a non-coordinating or weakly coordinating medium, with an acid of formula HX, wherein X represents a non-coordinating anion, said acid being used in a proportion not exceeding 2 molar equivalents per mole of Ru(II) complex.
Dependencies are inferred from the claim text.