US 5,874,479 A · Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same

Abstract

This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic permeation enhanced-wound healing compositions for enhancing the penetration of actives into membranes and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.D), the therapeutic wound healing composition comprises (a) lactate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In Embodiment Two (II), the therapeutic wound healing compositions of Embodiment One (I.A-D) are combined with a therapeutically effective amount of a permeation enhancing agent (PE) to form permeation enhanced-wound healing compositions (II.A-D+PE). This invention also pertains to methods for preparing and using the permeation enhanced-wound healing compositions and the topical and ingestible pharmaceutical products in which the therapeutic compositions may be used.

Claims34

Dependent claims

A therapeutic permeation enhanced-wound healing composition which comprises a therapeutically effective amount of a permeation enhancing agent and a wound healing composition, wherein the wound healing composition comprises:

(a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
(b) an antioxidant;
and
(c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the resuscitation of injured mammalian cells;
wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing.

2 more elements

An augmented permeation enhanced-wound healing composition which comprises:

(A) a therapeutic permeation enhanced-wound healing composition which comprises:
(1) a therapeutically effective amount of a permeation enhancing agent;
and
(2) a wound healing composition which comprises:
(a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
(b) an antioxidant;
and
(c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the repair of cellular membranes and resuscitation of mammalian cells;
wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing;
and,
(B) a medicament useful for treating wounds.

8 more elements

Dependencies are inferred from the claim text.

Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same

Life of this patent

Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same

Life of this patent

Abstract

Claims34