Isotonic fat emulsion containing omega-3-fatty acids and use thereof
AssigneeB. Braun Melsungen AG
InventorsJoerg Nehne, Michael Boll
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Abstract
Isotonic fat emulsions are provided which incorporate .omega.-3-fatty acids, .omega.-6-fatty acids, and medium-chain triglycerides. The emulsions are useful for parenteral application in post-aggression metabolism, in cases of chronic inflammatory diseases, and in neonatology and pediatrics. Due to the combination of .omega.-3-fatty acids and/or their physiologically acceptable esters with medium-chain-triglycerides, the medium-chain triglycerides are preferred to be oxidized in the organism, and the .omega.-3 fatty acids are protected from rapid oxidation, so that they are available to a higher extent for the formation of triply unsaturated eicosanoids. Furthermore, a liver protective effect is attained by the combination.
Claims3
An isotonic fat emulsion for parenteral administration comprising:
- at least one .omega.-3-fatty acid, said .omega.-3-fatty acid being essentially eicosapentaenoic acid, present as a component of marine oil derived from processing cold water fish,
- medium chain triglycerides comprising at least 90% caprylic and/or capric acid triglycerides by weight,
- at least one physiologically acceptable emulsifier, and
- at least one .omega.-6-fatty acid said .omega.-6-fatty acid being essentially linoleic acid, present as a component of soybean and/or safflower oil, at a content of 10% to 30% by weight of total lipid,
- the ratio of said .omega.-3-fatty acid to said medium chain triglycerides being between 1:9 and 3:5 by weight, the total fat content being between 5% and 30% by weight of said emulsion, and the emulsifier content being between 5% and 12% based on the weight of said fat content.
Dependencies are inferred from the claim text.