Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

A process for the preparation of a sulfoalkyl ether-cyclodextrin containing pharmaceutical dosage form comprising the steps of:

• forming a solid core comprising a physical mixture of a sulfoalkyl ether-cyclodextrin derivative, a pharmaceutical carrier and an effective amount of a therapeutic agent, a major portion of which is not complexed to the sulfoalkyl ether-cyclodextrin derivative;
• and
• coating said solid core with a film coating comprising a film forming agent and a pore forming agent to provide a pharmaceutically acceptable solid dosage form.

A solid pharmaceutical formulation comprising a film coating and a solid core, wherein the film coating comprises a film forming agent and a pore forming agent, and the solid core comprises a pharmaceutically acceptable carrier and a physical mixture of a therapeutically effective amount of a therapeutic agent and a sulfoalkyl ether-cyclodextrin (SAE-CD), wherein a major portion of the therapeutic agent is not complexed to the SAE-CD.