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US 5,874,312 AGranted
Diagnosis of alzheimer disease stage by mononuclear cell cytokine secretions
AssigneesBar-Ilan University, Mor Research Applications Ltd.
InventorsBenjamin Sredni, Moshe Huberman, Francis Shalit
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Abstract
A method of diagnosing and determining the disease stage of a degenerative disease of the central nervous system associated with the impairment of integrative brain function is disclosed. The method includes the steps of (a) measuring a cytokine production level of peripheral mononuclear cells from a peripheral blood sample and (b) determining the disease stage by comparing the level determined in step (a) with a level generated by age-matched normal controls.
Claims1
A method to assist in the diagnosis of possible Alzheimer's Disease in a patient comprising:
- (a) assessing a numeric score for cognitive impairment in the patient according to a record of independent living (RIL) method:
- (b) obtaining a blood sample from the assessment patient;
- (c) measuring the lectin-stimulated production of IL-6, TNF-.alpha., IFN-.gamma., and IL-2 cytokines and spontaneously secreted IL-3-LA from peripheral mononuclear cells from the blood sample;
- and
- (d) wherein a RIL score of 17-32, an increase in IL-6, decrease in IL-3-LA as compared to an age-matched healthy control or a RIL score, of 33-64, an increase in IL-6, TNF-.alpha., IFN-.gamma., and IL-2 as compared to an age-matched healthy control, are indicative of a diagnosis of possible Alzheimer's Disease.
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Dependencies are inferred from the claim text.