Protein disulfide isomerase and method of using
AssigneeTakeda Chemical Industries, Ltd.
InventorsKumao Toyoshima, Ryuya Horiuchi, Kiyoshi Yamauchi, Tadashi Yamamoto, Koichi Igarashi
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Abstract
Protein disulfide isomerase, which catalyzes the exchange reaction between sulfhydryl and disulfide in a protein for formation of the most stable natural type disulfide bonds, is useful for formation of natural type disulfide bonds in a protein which is produced in a prokaryotic cell.
Claims6
An isolated polypeptide comprising the amino acid sequence of FIG. 3.
A method for producing a protein of a eukaryotic organism having a natural type disulfide bond in its molecule, which comprises subjecting a protein of a eukaryotic organism produced from a recombinant prokaryotic cell, to a reaction with a polypeptide comprising the amino acid sequence of FIG. 3.
Dependencies are inferred from the claim text.