Incorporation of biological molecules into bioactive glasses
AssigneeThe Trustees of the University of Pennsylvania
InventorsPaul Ducheyne, Shulamith Radin, Erick Manuel Santos
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Abstract
Carriers comprising silica-based glass providing for the controlled release of biologically active molecules, their methods of preparation, and methods of use are disclosed. The carriers are prepared using a sol-gel-derived process. Biologically active molecules are incorporated within the matrix of the glass during production.
Claims33
A controlled-release carrier comprising bioactive silica-based glass having a porous matrix and biologically active molecules incorporated throughout said matrix of said glass, wherein said carrier is prepared using a sol-gel derived process, and said biologically active molecules are incorporated during the liquid phase of the sol, at a temperature of about 40.degree. C. or below.
A controlled-release carrier comprising bioactive silica-based glass having a porous matrix and biologically active molecules incorporated throughout said matrix, said carrier having been immersed in a solution with an ion content similar to interstitial fluid for a period of up to about seven days.
Dependencies are inferred from the claim text.