Method of reducing an immune response to a recombinant adenovirus
AssigneesThe Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
InventorsJames M. Wilson, Yiping Yang, Giorgio Trinchieri
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Abstract
A method of reducing an immune response to a recombinant adenovirus which involves co-administration of the recombinant adenovirus and a selected immune modulator. The immune modulator functions by inhibiting the formation of neutralizing antibodies and/or reducing CTL killing of the virally infected cells. The method additionally encompasses the step of re-administering the recombinant adenovirus.
Claims21
A method of inhibiting in a mammal formation of neutralizing antibodies directed against a recombinant adenovirus comprising the step of co-administering to said mammal said adenovirus and an antibody directed against CD4, wherein formation of neutralizing antibodies is inhibited.
A method of inhibiting in a mammal formation of neutralizing antibodies directed against a recombinant adenovirus comprising the step of co-administering to said mammal said adenovirus and interleukin-12, wherein formation of neutralizing antibodies is inhibited.
A method of inhibiting in a mammal formation of neutralizing antibodies directed against a recombinant adenovirus comprising the step of co-administering to said mammal said adenovirus and interferon-gamma, wherein formation of neutralizing antibodies is inhibited.
A method of inhibiting in a mammal formation of neutralizing antibodies directed against a recombinant adenovirus comprising the step of co-administering to said mammal said adenovirus and an antibody directed against CD40 ligand, wherein formation of neutralizing antibodies is inhibited.
Dependencies are inferred from the claim text.