Graft co-polymer adducts of platinum (II) compounds
AssigneeThe General Hospital Corporation
InventorsAlexei Bogdanov, Ralph Weissleder, Thomas J. Brady
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Abstract
A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the protective chain, and a reversibly linked Pt(II) compound. The invention also relates to a method of treating a disease in a patient, particularly cancer, by administering to the patient a therapeutically effective amount of the adduct, and may include scanning the patient using an imaging technique which can provide a visible image of the distribution of the adduct.
Claims49
A biocompatible platinum-carrying adduct, comprising:
- (i) a polymeric carrier;
- (ii) a plurality of polymeric protective side chains, wherein said plurality corresponds to a number between 15% and 30%, inclusive, of the number of monomeric units in the polymeric backbone;
- and wherein each protective side chain, independently,
- (a) is covalently linked to said backbone,
- (b) has a molecular weight between 500 and 10,000 Daltons, and
- (c) comprises a polyethylene glycol derivative;
- and
- (iii) a plurality of platinum-carrying side groups, wherein each platinum-carrying side group, independently,
- (1) is covalently linked to said backbone,
- (2) is dissociably linked to a platinum (II) compound, and
- (3) has a molecular weight independently less than 465 Daltons, exclusive of said platinum (II) compound.
A biocompatible graft co-polymer adduct comprising:
- a polymeric carrier;
- a protective chain linked to said polymeric carrier;
- a platinum(II) compound reversibly linked to said polymeric carrier and said protective chain;
- and,
- a contrast agent comprising a paramagnetic element linked to said polymeric carrier or to said polymeric carrier and said protective chain.
Dependencies are inferred from the claim text.