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AssigneesBoard of Regents, The University of Texas System, The Texas A&M University System
InventorsR. E. Garfield, A. T. Balaban, W. A. Seitz
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The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric oxide-containing emulsions may be used for the administration of nitric oxide to individuals in need thereof. Individuals in need of nitric oxide administration can include those suffering from hypertension, preeclampsia and a number of other situations where an increased blood flow, for example, is desirable. In addition, given the long use of perfluoro compound emulsions as blood substitutes, the present invention provides a relatively safe mode for administering and distributing nitric oxide-without potential negative side effects such as toxicities due to drug metabolites.
A composition consisting essentially of a perfluoro compound emulsion with nitric oxide dissolved therein.
A method for preparing a nitric oxide source suitable for in vivo administration, the method comprising preparing or obtaining an emulsion consisting essentially of a perfluoro compound having nitric oxide dissolved in said emulsion.
A method for treating a mammal with nitric oxide comprising administering a composition consisting essentially of a perfluoro compound emulsion and nitric oxide in a therapeutically effective amount.
A method for treating hypertension comprising administering a composition consisting essentially of a perfluoro compound emulsion with nitric oxide dissolved therein in a therapeutically effective amount.
Dependencies are inferred from the claim text.