Sulfonamido substituted benzopyran derivatives

A compound of the formula ##STR117## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is ##STR118## R.sup.2 is hydrogen, hydroxy, or --OC(O)R.sup.14 ;

• R.sup.3 and R.sup.4 are each independently hydrogen, alkyl or arylalkyl;
• or R.sup.3 and R.sup.4 taken together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring;
• R.sup.5 is hydrogen, alkyl, halogen, heterocyclo, nitrile, haloalkyl or aryl;
• R.sup.6 and R.sup.7 are independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, haloalkyl, hydroxyalkyl, hydroxyalkyl substituted with a carboxylic ester or carboxylic acid, alkoxyalkyl, thioalkyl, (cycloalkyl)alkyl, morpholinylalkyl, heterocyclo or (heterocyclo) alkyl;
• or R.sup.6 and R.sup.7 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered mono or bicyclic ring including a fused ring which is 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 4-thiamorpholine dioxide, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl;
• or 1-piperazinyl, 1-pyrrolidinyl, 1-piperidinyl or 1-azepinyl substituted with one or more alkyl, alkoxy, alkylthio, halo, trifluoromethyl, hydroxy, aryl, arylalkyl, --COOR.sup.14 or --CO--substituted amino;
• or R.sup.5 and R.sup.6 taken together with the atoms to which they are attached form a 5- to 7-membered ring which contains two hetero atoms optionally substituted with aryl;
• R.sup.8 is aryl;
• R.sup.9 is hydrogen or alkyl;
• R.sup.10 and R.sup.11 are independently hydrogen, alkyl, alkenyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl;
• or R.sup.11 can be an aryl group fused to 2 carbon atoms of the cyanoguanidine ring portion;
• R.sup.14 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl;
• Y is --O--;
• Z is NCN;
• n is an integer of 1 to 3.