Use of neuro-glial cell lines for transplantation therapy
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsEugene O. Major, Carlo S. Tornatore
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Abstract
Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.
Claims10
A method for treating a mammal having a neurological syndrome or disease characterized by a dopamine deficiency comprising implanting into said mammal a therapeutically effective amount of a nontumorigenic and noninflammatory immortalized human neuro-glial cell line comprising a heterologous nucleic acid sequence which encodes a biologically active peptide, wherein said cell line is capable of 1) expressing said heterologous nucleic acid sequence and 2) inducing neuro migration or neurite extension in the mammal and wherein the biologically active peptide alleviates the neurological disorder characterized by a dopamine deficiency.
A method for treating a mammal having Parkinson's Disease comprising implanting into the basal ganglia of said mammal a therapeutically effective amount of a nontumorigenic and noninflammatory immortalized human neuro-glial cell line comprising a heterologous nucleic acid sequence which encodes a biologically active tyrosine hydroxylase, wherein said cell line is capable of 1) expressing said heterologous nucleic acid sequence and 2) inducing neuro migration or neurite extension in the mammal.
Dependencies are inferred from the claim text.