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US 5,869,079 AGranted
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
AssigneeOculex Pharmaceuticals, Inc.
InventorsVernon Wong, Frank Kochinke
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Abstract
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide controlled, sustained drug release for an extended period of time.
Claims1
An semi-rigid implant for sustained release comprising:
- a polyester of lactic acid and glycolic acid in from 10 to 50 weight percent of said implant;
- hydroxylpropylmethylcellulose in from 10 to 50 weight percent of said implant;
- and
- dexamethasone, wherein said dexamethasone is released within a therapeutic dosage which does not vary by more than about 100% for a period of at least about 3 days.
1 more element
Dependencies are inferred from the claim text.